H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization

H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization

The protein kinases Mst1 and Mst2 have tumor suppressor activity, but their mode of regulation is not well established. Mst1 and Mst2 are broadly expressed and may have certain overlapping functions in mammals, as deletions of both Mst1 and Mst2 together are required for tumorigenesis in mouse models [1-3]. These kinases act via a three-component signaling cascade comprising Mst1 and Mst2, the ...

The hippo pathway.

The Hippo pathway (Fig. 1), also known as the SalvadorWarts-Hippo pathway, regulates tissue growth in a wide variety of organisms (Harvey and Tapon 2007; Grusche et al. 2010; Oh and Irvine 2010; Pan 2010; Halder and Johnson 2011; Zhao et al. 2011). Many components of the pathway were identified as a result of mutations in the fruit fly Drosophila melanogaster that resulted in tissue overgrowth ...

Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway

Despite recent progress in research on the Hippo signalling pathway, the structural information available in this area is extremely limited. Intriguingly, the homodimeric and heterodimeric interactions of mammalian sterile 20-like (MST) kinases through the so-called `SARAH' (SAV/RASSF/HPO) domains play a critical role in cellular homeostasis, dictating the fate of the cell regarding cell prolif...

The Hippo signaling pathway interactome.

The Hippo pathway controls metazoan organ growth by regulating cell proliferation and apoptosis. Many components have been identified, but our knowledge of the composition and structure of this pathway is still incomplete. Using existing pathway components as baits, we generated by mass spectrometry a high-confidence Drosophila Hippo protein-protein interaction network (Hippo-PPIN) consisting o...

SnapShot: The Hippo Signaling Pathway